Weight Loss Medications Comparison 2025

Mounjaro vs Wegovy vs Ozempic vs Saxenda - Which is Right for You?

Updated: 05 July 2025 | 12 min read

This comparison is for educational purposes. Always consult with a healthcare provider to determine which medication is appropriate for your individual needs.

Quick Comparison Table

Medication Active Ingredient Average Weight Loss Injection Frequency Monthly Cost (UK)
Mounjaro Tirzepatide 15-22% Weekly £120-350
Wegovy Semaglutide 2.4mg 12-15% Weekly £200-300
Ozempic Semaglutide 1mg 8-12% Weekly £130-250
Saxenda Liraglutide 5-10% Daily £150-250

Detailed Medication Profiles

Mounjaro (Tirzepatide)

Pros:
  • Highest average weight-loss
  • Dual hormone action (GIP/GLP-1)
  • Once weekly injection
  • Good availability in UK
Cons:
  • Can be expensive at higher doses
  • Newer medication (less long-term data)
  • Common GI side effects initially

Best for: Those seeking maximum weight-loss who can tolerate gradual dose escalation.

Wegovy (Semaglutide 2.4mg)

Pros:
  • Specifically approved for weight-loss
  • Extensive clinical trial data
  • Once weekly injection
  • Proven cardiovascular benefits
Cons:
  • Supply shortages in UK
  • Expensive when available
  • May cause nausea

Best for: Those who want a well-established weight-loss medication with strong clinical evidence.

Ozempic (Semaglutide 1mg)

Pros:
  • More affordable than Wegovy
  • Better availability
  • Once weekly injection
  • Diabetes benefits
Cons:
  • Lower dose than Wegovy
  • Off-label for weight-loss
  • Less weight-loss than Wegovy/Mounjaro

Best for: Those with type 2 diabetes or seeking a more affordable semaglutide option.

Saxenda (Liraglutide)

Pros:
  • Established safety profile
  • Approved for weight-loss
  • Can work when others fail
Cons:
  • Daily injections required
  • Less effective than newer options
  • More injection site reactions

Best for: Those who haven't responded to weekly medications or prefer daily dosing.

Side Effects Comparison

All GLP-1 medications share similar side effects, typically most pronounced when starting or increasing doses:

Most Common
  • ✓ Nausea
  • ✓ Diarrhea
  • ✓ Constipation
  • ✓ Vomiting
  • ✓ Decreased appetite
Less Common
  • ✓ Headache
  • ✓ Fatigue
  • ✓ Dizziness
  • ✓ Heartburn
  • ✓ Hair loss (rare)
Serious (Rare)
  • ⚠️ Pancreatitis
  • ⚠️ Gallbladder problems
  • ⚠️ Kidney problems
  • ⚠️ Allergic reactions
  • ⚠️ Thyroid tumors

How to Choose

  • Maximum weight-loss: Mounjaro or Wegovy
  • Moderate weight-loss: Ozempic
  • Modest weight-loss: Saxenda

Use our price comparison tool to find current best prices. Generally:

  • Most affordable: Starting doses of any medication
  • Best value: Mounjaro (considering effectiveness)
  • Budget option: Ozempic (if weight-loss goals are moderate)

As of 2025 in the UK:

  • Best availability: Mounjaro, Ozempic
  • Limited availability: Wegovy (frequent shortages)
  • Good availability: Saxenda

Starting Your Weight Loss Journey

  1. Consult a healthcare provider - Discuss your medical history and goals
  2. Get baseline measurements - Weight, BMI, blood tests
  3. Choose your medication - Based on effectiveness, cost, and availability
  4. Find the best price - Use our comparison tool
  5. Start slowly - Follow the dosing schedule
  6. Track progress - Weight, measurements, how you feel
  7. Adjust as needed - Work with your provider
Remember

All weight-loss medications work best when combined with:

  • Reduced calorie diet
  • Regular physical activity
  • Behavioral changes
  • Adequate sleep
  • Stress management
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